Publications and Dissemination of Results

Coming up:

Dissemination of an open-source tool to calculate cellular distribution and association in 3D environments on the BioBlood website. In progress.

BIOBLOOD Results have been recently presented at: IMG_7203

TedTalk by Prof. Mantalaris and Dr. Panoskaltsis, University of Crete, September 2018

Dr. Ana Luz Campano Quiroga presents “Mathematical model to predict chemotherapy outcomes” at the Imperial College Chemical Engineering PostDoc Symposium on 25 April 2018.

BioBlood Symposium  was organised on 20 April 2018, at Imperial College London (SymposiumLeafletv2): presentations available to watch!

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Poster presentation “Primary Chronic Lymphocytic Leukemia Cells Can be Maintained Long-Term in Serum-Free, Cytokine-Free 3D Culture”, American Society of Hematology, December 2017. Presenter: Joana Dos Santos.

An ex vivo dynamic model of human erythropoiesis in a 3D perfusion hollow fibre bioreactor. Francis Crick Institute Stem Cell Club. London, UK, November 2017. Speaker: Mark Allenby

International Seminar Series: Researchers in Action, “Stem cell bioreactors: recapitulating marrow physiology for personalized blood therapy”, Universidad de La Frontera, Temuco, Chile, October 2017, Speaker: Mark Allenby

Mark Allenby is awarded the best oral presentation prize: “Quantitative imaging of ex vivo niche formation within a hollow fibre bioreactor for physiological in vitro human red cell production” at TCES, UK.

IMG_3052Asma Tahlawi, Joana dos Santos and Susana Britos dos Santos present posters on BIOBLOOD results and engage with the audience, at the Imperial College Chemical Engineering PhD symposium, July 2017.

Mark Allenby is awarded the prize for best oral presentation: “Engineering a marrow-mimetic environment for human blood production”, Imperial College Chemical Engineering PhD symposium, July 2017.

Poster presentation: A framework for the personalized treatment of Acute Myeloid Leukaemia (AML)” at the APM forum, April 2017. Speaker: S. V. Savvopoulos

Imperial College Stem and Regenerative Medicine Network (ICRMN) Symposium: “Spatiotemporal mapping of erythroid, stromal, and osteogenic niche formation to support physiologic red cell production in a three-dimensional hollow fibre perfusion bioreactor.” Hammersmith Hospital, 21 February, 2017.  Speaker: Mark AllenbyIMG_3011

Invited Seminar by Dr. Ir Eirini Velliou, Title: Engineering a bone marrow mimicry: towards physiological production of human red blood cells in vitro”, University of Surrey, Chemical and Process Engineering, on 23 November 2016; Speakers: Susana Brito dos Santos, Mark Allenby

Biological Making (BioMaker) Workshop: “Engineering a marrow mimicry reactor towards physiological production of red cells.” University College London, 24 March, 2016; Speaker: Mark Allenby.

Published papers and Conference Proceedings:

Title: RGD‐functionalized polyurethane scaffolds promote umbilical cord blood mesenchymal stem cell expansion and osteogenic differentiation

Authors: Asma Tahlawi , Michail E. Klontzas , Mark C. Allenby , José C.F. Morais , Nicki Panoskaltsis , Athanasios Mantalaris

TitleA 3D bioinspired highly porous scaffolding system for modelling of pancreatic ductal adenocarcinoma

Authors: Stella Totti , Mark C. Allenby , Susana Brito Dos Santos , Athanasios Mantalaris , Eirini G. Velliou

Title: Ceramic hollow fibre constructs for continuous perfusion and cell harvest from 3D hematopoietic organoids

Authors: Mark Allenby, Asma Tahlawi, José C.F. Morais, Kang Li, Nicki Panoskaltsis, and Athanasios Mantalaris

Title: Stem cell biomanufacturing under uncertainty: A case study in optimizing red blood cell production

Authors: Ruth Misener, Mark Allenby, Maria Fuentes-Gari, Karan Gupta, Thomas Wiggins, Nicki Panoskaltsis , Efstratios N. Pistikopoulos , Athanasios Mantalaris

Title:  A Personalized Framework for Dynamic Modeling of Disease Trajectories in Chronic Lymphocytic Leukemia

Authors: Symeon Savvopoulos , Ruth Misener , Nicki Panoskaltsis , Efstratios Pistikopoulos , Athanasios Mantalaris

Title: Polyurethane scaffolds seeded with CD34+ cells maintain early stem cells whilst also facilitating prolonged egress of haematopoietic progenitors

Authors: Charlotte E. Severn , Hugo Macedo , Mark J. Eagle , Paul Rooney , Athanasios Mantalaris , Ashley M. Toye

Title: Towards unravelling the kinetics of an acute myeloid leukaemia model system under oxidative and starvation stress: a comparison between two- and three-dimensional cultures

Authors: Eirini G. Velliou , Susana Brito Dos Santos , Maria M. Papathanasiou , Maria Fuentes-Gari , Ruth Misener , Nicki Panoskaltsis , Efstratios N. Pistikopoulos, Athanasios Mantalaris

Title: Global superstructure optimisation of red blood cell production in a parallelised hollow fibre bioreactor

Authors: Ruth Misener , María Fuentes Garí , Maria Rende , Eirini Velliou , Nicki Panoskaltsis , Efstratios N. Pistikopoulos , Athanasios Mantalaris

Title: A mathematical model of subpopulation kinetics for the deconvolution of leukaemia heterogeneity

Authors: María Fuentes-Garí , Ruth Misener , David García-Munzer , Eirini Velliou , Michael C. Georgiadis , Margaritis Kostoglou , Efstratios N. Pistikopoulos , Nicki Panoskaltsis , Athanasios Mantalaris

Title: A systematic framework for the design, simulation and optimization of personalized healthcare: Making and healing blood

Authors: María Fuentes-Garí , Eirini Velliou , Ruth Misener , Eleni Pefani , Maria Rende , Nicki Panoskaltsis , Athanasios Mantalaris , Efstratios N. Pistikopoulos

Title: Selecting a Differential Equation Cell Cycle Model for Simulating Leukemia Treatment

Authors: María Fuentes-Garí , Ruth Misener , Michael C. Georgiadis , Margaritis Kostoglou , Nicki Panoskaltsis , Athanasios Mantalaris , Efstratios N. Pistikopoulos

Title: Chemotherapy Drug Scheduling for the Induction Treatment of Patients With Acute Myeloid Leukemia

Authors: E. Pefani , N. Panoskaltsis , A. Mantalaris , M. C. Georgiadis , E. N. Pistikopoulos

Title: A Quantitative Three-Dimensional Image Analysis Tool for Maximal Acquisition of Spatial Heterogeneity Data

Authors: Mark C. Allenby , Ruth Misener , Nicki Panoskaltsis , Athanasios Mantalaris

Title: Early Erythroid Development Is Enhanced with Hypoxia and Terminal Maturation with Normoxia in a 3D Ex Vivo Physiologic Eythropoiesis Model

Authors: Susana Brito dos Santos, Mark C. Allenby, Athanasios Mantalaris, Nicki Panoskaltsis

Title: Spatiotemporal Mapping of Erythroid, Stromal, and Osteogenic Niche Formation to Support Physiologic Red Cell Production in a Three-Dimensional Hollow Fibre Perfusion Bioreactor

Authors: Mark C. Allenby, Asma Tahlawi, Ruth Misener, Susana Brito dos Santos, Athanasios Mantalaris and Nicki Panoskaltsis

Title: Effect of Oxygen and 3D Microenvironment on Physiologic Erythropoiesis

Authors: Susana Brito dos Santos, Mark C. Allenby, Athanasios Mantalaris, Nicki Panoskaltsis

Title: In Vitro Physiologic Erythropoiesis in a 3D Bone Marrow Biomimicry

Authors:  S. Brito dos Santos, M. C. Allenby, N. Panoskaltsis, A. Mantalaris

Title: A Personalized Framework for Dynamic Modeling of Disease Trajectories in Chronic Lymphocytic Leukemia

Authors: Symeon Savvopoulos , Ruth Misener , Nicki Panoskaltsis , Efstratios Pistikopoulos , Athanasios Mantalaris

Title: Polyurethane scaffolds seeded with CD34+ cells maintain early stem cells whilst also facilitating prolonged egress of haematopoietic progenitors

Authors: Charlotte E. Severn , Hugo Macedo , Mark J. Eagle , Paul Rooney , Athanasios Mantalaris , Ashley M. Toye.

Title: Cell cycle model selection for leukemia and its impact in chemotherapy outcomes 

Authors: María Fuentes-Garí , Ruth Misener , Eleni Pefani , David García-Münzer , Margaritis Kostoglou , Michael C. Georgiadis , Nicki Panoskaltsis , Efstratios N. Pistikopoulos , Athanasios Mantalaris

Title: Robust Superstructure Optimisation of a Bioreactor that Produces Red Blood Cells

Authors: Ruth Misener , Jonathan Chin , Min Lai , María Fuentes Garí , Eirini Velliou , Nicki Panoskaltsis , Efstratios N. Pistikopoulos , Athanasios Mantalaris

Title: A framework for the design, modeling and optimization of biomedical systems

Authors: Eirini Velliou , María Fuentes-Garí , Ruth Misener , Eleni Pefani , Maria Rende , Nicki Panoskaltsis , Athanasios Mantalaris , Efstratios N. Pistikopoulos

Title: A systematic framework for the design, simulation and optimization of personalized healthcare: Making and healing blood

Authors: María Fuentes-Garía,Eirini Velliou, Ruth Misener, Eleni Pefani, Maria Rende, Nicki Panoskaltsis, Athanasios Mantalaris, Efstratios N. Pistikopoulos

Title: Global Sensitivity Analysis for a Model of B-Cell Chronic Lymphocytic Leukemia Disease Trajectories

Authors: Symeon Savvopoulos , Ruth Misener , Nicki Panoskaltsis , Efstratios N. Pistikopoulos , Athanasios Mantalaris

Title: Cell cycle model selection for leukemia and its impact in chemotherapy outcomes

Authors: María Fuentes-Garí , Ruth Misener , Eleni Pefani , David García-Münzer , Margaritis Kostoglou , Michael C. Georgiadis , Nicki Panoskaltsis , Efstratios N. Pistikopoulos , Athanasios Mantalaris

Title: Chemotherapy Optimization in Leukemia: Selecting the Right Mathematical Models for the Right Biological Processes

Authors: María Fuentes-Garí, Ruth Misener, Michael C. Georgiadis, Margaritis Kostoglou, Nicki Panoskaltsis, Athanasios Mantalaris, Efstratios N. Pistikopoulos

Title: Development of an ex vivo bone marrow mimicry microenvironment in a novel 3D hollow fibre bioreactor

Authors: Mark C. Allenby, Asma Tahlawi, Susana Brito dos Santos, Ruth Misener, Yu-Shik Hwang, Nicki Panoskaltsis, Athanasios Mantalaris

Title: Development of a Hematopoietic Microenvironmentfor the Production of Red Blood Cells (RBCs) in a Novel 3D Hollow Fibre Bioreactor

Authors: M. C. Allenby, A. Tahlawi, S. B. Dos Santos, R. Misener, Y. Hwang, N. Panoskaltsis, A. Mantalaris